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PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer's Disease and Parkinson's Disease

Journal

FRONTIERS IN PHARMACOLOGY
Volume 12, Issue -, Pages -

Publisher

FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2021.648636

Keywords

PI3K; Akt signal pathway; neurodegenerative diseases; Alzheimer’ s disease; Parkinson’ s disease; natural products; nerve protection

Funding

  1. Science and Technology Key Program of Hunan Province [2016SK 2066]
  2. Key Projects of Hunan Health Committee [B2017207]
  3. Hunan Province Chinese Medicine Research Program [201940]
  4. Changsha City Science and Technology Program Grants [kq1801144]
  5. Changsha Central Hospital Affiliated to University of South China Foundation of key Program [YNKY201901]
  6. Hunan Province Foundation of High-level Health Talent (225 Program)
  7. Science and Technology Key Program of Hunan Provincial Health Committee [20201904]

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Alzheimer's disease and Parkinson's disease are two typical neurodegenerative diseases that increase with aging, and are related to the PI3K/AKT signaling pathway. Natural products can play a neuroprotective role by activating this pathway, potentially serving as a source for disease treatment.
Alzheimer's disease (AD) and Parkinson's disease (PD) are two typical neurodegenerative diseases that increased with aging. With the emergence of aging population, the health problem and economic burden caused by the two diseases also increase. Phosphatidylinositol 3-kinases/protein kinase B (PI3K/AKT) signaling pathway regulates signal transduction and biological processes such as cell proliferation, apoptosis and metabolism. According to reports, it regulates neurotoxicity and mediates the survival of neurons through different substrates such as forkhead box protein Os (FoxOs), glycogen synthase kinase-3 beta (GSK-3 beta), and caspase-9. Accumulating evidences indicate that some natural products can play a neuroprotective role by activating PI3K/AKT pathway, providing an effective resource for the discovery of potential therapeutic drugs. This article reviews the relationship between AKT signaling pathway and AD and PD, and discusses the potential natural products based on the PI3K/AKT signaling pathway to treat two diseases in recent years, hoping to provide guidance and reference for this field. Further development of Chinese herbal medicine is needed to treat these two diseases.

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