Journal
FRONTIERS IN NEUROSCIENCE
Volume 15, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnins.2021.668243
Keywords
ID4; ependymal cell; development; brain; transcription factor
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Funding
- ATIP-AVENIR Program
- Ligue Nationale Contre le Cancer (Comite de Paris) [RS14/75-113]
- Fondation ARC [PJA 20131200481]
- Valencian Council for Innovation, Universities, Science and Digital Society [PROMETEO/2019/075]
- Red de Terapia Celular [TerCelRD16/0011/0026]
- Spanish Ministry of Science, Innovation and Universities [PCI2018-093062]
- Marie Curie grant [661044]
- H2020 Marie Sklodowska-Curie
- Ligue Nationale Contre le Cancer (Comite de Paris)
- Fondation ARC
- Marie Curie Actions (MSCA) [661044] Funding Source: Marie Curie Actions (MSCA)
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Ependymal cells, derived from radial glia, are crucial for proper cerebrospinal fluid flow and neurogenesis modulation. The transcriptional regulator ID4 plays a significant role in the development and maturation of ependymal cells.
Ependymal cells are radial glia-derived multiciliated cells lining the lateral ventricles of the brain and spinal cord. Correct development and coordinated cilia beating is essential for proper cerebrospinal fluid (CSF) flow and neurogenesis modulation. Dysfunctions of ependymal cells were associated with transcription factor deregulation. Here we provide evidence that the transcriptional regulator ID4 is involved in ependymal cell development and maturation. We observed that Id4-deficient mice display altered ventricular cell cytoarchitecture, decreased ependymal cell number and enlarged ventricles. In addition, absence of ID4 during embryonic development resulted in decreased ependymal cell number and delayed maturation. Our findings open the way for a potential role of ID4 in ependymal cell development and motor cilia function.
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