Journal
FRONTIERS IN NEUROSCIENCE
Volume 15, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnins.2021.644239
Keywords
central nervous system; traumatic brain injury; spinal cord injury; circular RNAs; inflammation; apoptosis
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Funding
- National Natural Science Foundation of China [81572229, 81972138]
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Recent studies have shown that circRNAs play important roles in CNS post-traumatic injury, associated with proliferation, inflammation, and apoptosis. The potential clinical value of circRNAs as a therapeutic target for CNS injury is discussed, bringing new possibilities for treatment.
The central nervous system (CNS) post-traumatic injury can cause severe nerve damage with devastating consequences. However, its pathophysiological mechanisms remain vague. There is still an urgent need for more effective treatments. Circular RNAs (circRNAs) are non-coding RNAs that can form covalently closed RNA circles. Through second-generation sequencing technology, microarray analysis, bioinformatics, and other technologies, recent studies have shown that a number of circRNAs are differentially expressed after traumatic brain injury (TBI) or spinal cord injury (SCI). These circRNAs play important roles in the proliferation, inflammation, and apoptosis in CNS post-traumatic injury. In this review, we summarize the expression and functions of circRNAs in CNS in recent studies, as well as the circRNA-miRNA-mRNA interaction networks. The potential clinical value of circRNAs as a therapeutic target is also discussed.
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