Journal
EMERGING MICROBES & INFECTIONS
Volume 10, Issue 1, Pages 982-993Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/22221751.2021.1925161
Keywords
Blood virome; virosphere; metagenomic next-generation sequencing; fever; children
Categories
Funding
- Bill and Melinda Gates Foundation [OPP1163434]
- Swiss National Science Foundation [320030_179507]
- Swiss National Science Foundation (SNF) [320030_179507] Funding Source: Swiss National Science Foundation (SNF)
- Bill and Melinda Gates Foundation [OPP1163434] Funding Source: Bill and Melinda Gates Foundation
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This study explored the blood virome of febrile children in sub-Saharan Africa, identifying common viruses causing human infection/disease in half of the patients. It also detected a number of viruses related to arthropod, vertebrate, or mammalian species that have not yet been known to cause human infection/disease, highlighting the need for further surveillance of emerging pathogens.
Viral infections are the leading cause of childhood acute febrile illnesses motivating consultation in sub-Saharan Africa. The majority of causal viruses are never identified in low-resource clinical settings as such testing is either not part of routine screening or available diagnostic tools have limited ability to detect new/unexpected viral variants. An indepth exploration of the blood virome is therefore necessary to clarify the potential viral origin of fever in children. Metagenomic next-generation sequencing is a powerful tool for such broad investigations, allowing the detection of RNA and DNA viral genomes. Here, we describe the blood virome of 816 febrile children (<5 years) presenting at outpatient departments in Dar es Salaam over one-year. We show that half of the patients (394/816) had at least one detected virus recognized as causes of human infection/disease (13.8% enteroviruses (enterovirus A, B, C, and rhinovirus A and C), 12% rotaviruses, 11% human herpesvirus type 6). Additionally, we report the detection of a large number of viruses (related to arthropod, vertebrate or mammalian viral species) not yet known to cause human infection/disease, highlighting those who should be on the radar, deserve specific attention in the febrile paediatric population and, more broadly, for surveillance of emerging pathogens.
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