4.6 Article

Flightless I Homolog Reverses Enzalutamide Resistance through PD-L1-Mediated Immune Evasion in Prostate Cancer

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Article Medicine, Research & Experimental

ACSS3 represses prostate cancer progression through downregulating lipid droplet-associated protein PLIN3

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Summary: This study identified downregulation of ACSS3 in prostate cancer due to gene promoter methylation, with restoration of ACSS3 expression reducing LD deposits, promoting apoptosis, decreasing androgen synthesis, inhibiting CRPC progression, and reversing Enzalutamide resistance. Mechanistically, ACSS3 reduced LD deposits by regulating the stability of the LD coat protein PLIN3, thereby repressing prostate cancer progression.

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