Journal
BRAIN AND BEHAVIOR
Volume 11, Issue 6, Pages -Publisher
WILEY
DOI: 10.1002/brb3.2142
Keywords
case‐ control study; early‐ onset seizures; meta‐ analysis; risk factors; stroke
Categories
Funding
- Shaanxi Province Key RD Project [2019ZDLSF04-06--01]
- Shaanxi Province Traditional Chinese Medicine Brain Disease Clinical Medicine Research Center [201704]
- Discipline Innovation Team Building Project of Shaanxi University of Traditional Chinese Medicine [2019-YL15]
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By systematically evaluating the risk factors of early-onset seizures after stroke, it was found that factors related to cortical involvement, cerebral infarction with hemorrhagic transformation, and intracerebral hemorrhage have a greater association with the occurrence of early-onset seizures.
Objectives To systematically evaluate the risk factors of early-onset seizures after stroke, in order to better provide evidence-based results for early detection, identification, targeted prevention, and treatment of this disease. Methods PubMed, EMBASE, The Cochrane Library, CNKI, and WanFang databases were searched to collect relevant studies on the risk factors of early-onset seizures after stroke from January 2010 to January 2020. Meta-analysis of all included studies was performed by using RevMan version 5.3 and Stata version 14.0 software. Results Eighteen case-control studies with a total sample size of 13,289 cases, including 813 cases with early-onset seizures after stroke, and 12,476 cases with non-early-onset seizures after stroke were included. The results of meta-analysis showed that cortical involvement [Odds Ratio (OR) = 5.00, 95%Confidence Interval (CI) (2.85, 8.74), p < .00001], cerebral infarction with hemorrhagic transformation [OR = 2.77, 95%CI (1.87, 4.11), p < .00001] and intracerebral hemorrhage [OR = 1.83, 95%CI (1.13, 2.97), p = .01]-related factors showed greater association with the occurrence of early-onset seizures after stroke. Conclusions These findings suggest that cortical involvement, intracerebral hemorrhage, and cerebral infarction with hemorrhagic transformation are important predictors and risk factors for early seizures after stroke, while the patient's gender, age, NHISS score, alcoholism, smoking, high blood pressure, diabetes, atrial fibrillation, dyslipidemia, receiving surgical treatment, and reperfusion therapy showed no association with the occurrence of early-onset seizures after stroke.
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