4.5 Article

Associations between coronary heart disease and risk of cognitive impairment: A meta-analysis

Journal

BRAIN AND BEHAVIOR
Volume 11, Issue 5, Pages -

Publisher

WILEY
DOI: 10.1002/brb3.2108

Keywords

Alzheimer' s disease; coronary heart disease; dementia; meta‐ analysis

Funding

  1. Natural Science Foundation of Jiangsu Province [BK20181505]

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In summary, this meta-analysis found that coronary heart disease is significantly associated with an increased risk of cognitive impairment, including myocardial infarction. However, no significant association was found between angina pectoris and cognitive impairment. Subgroup studies also indicated that CHD patients are at higher risk for vascular dementia.
Background Several studies have demonstrated that coronary heart disease (CHD) is a high risk factor for cognitive impairment, whereas other studies showed that there was no association between cognitive impairment and CHD. The relationship between CHD and cognitive impairment is still unclear based on these conflicting results. Thus, it is of importance to evaluate the association between CHD and cognitive impairment. The present study made a meta-analysis to explore the association between CHD and risk of cognitive impairment. Methods Articles exploring the association between CHD and cognitive impairment and published before November 2020 were searched in the following databases: PubMed, Web of Science, Medline, EMBASE, and Google Scholar. We used STATA 12.0 software to compute the relative risks (RRs), odds ratios (ORs), or hazard ratios (HRs) and 95% confidence intervals (CIs). Results The meta-analysis showed a positive association between CHD and risk of all-cause cognitive impairment with a random effects model (RR = 1.27, 95% CI 1.18 to 1.36, I-2 = 82.8%, p < .001). Additionally, the study showed a positive association between myocardial infraction (MI) and risk of all-cause cognitive impairment with a random effects model (RR = 1.49, 95% CI 1.20 to 1.84, I-2 = 76.0%, p < .001). However, no significant association was detected between angina pectoris (AP) and risk of all-cause cognitive impairment with a random effects model (RR = 1.23, 95% CI 0.95 to 1.58, I-2 = 79.1%, p < .001). Subgroup studies also showed that CHD patients are at higher risk for vascular dementia (VD), but not Alzheimer's disease (AD) (VD: RR = 1.34, 95% CI: 1.28-1.39; AD: RR = 0.99, 95% CI: 0.92-1.07). Conclusion In a word, CHD was significantly associated with an increased risk of developing cognitive impairment.

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