Journal
MICROMACHINES
Volume 12, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/mi12050470
Keywords
organs-on-a-chip; body-on-a-chip; micro-physiological systems; bioprinting; lung-on-a-chip; liver-on-a-chip; skin-on-a-chip; kidney-on-a-chip; heart-on-a-chip
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Funding
- TU Wien University Library
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Organ-on-a-chip technology has emerged as a crucial tool in pharmaceutical and toxicological research over the past decade, with the need for further validation in clinical and pharmaceutical settings.
Organ-on-a-chip technology has the potential to accelerate pharmaceutical drug development, improve the clinical translation of basic research, and provide personalized intervention strategies. In the last decade, big pharma has engaged in many academic research cooperations to develop organ-on-a-chip systems for future drug discoveries. Although most organ-on-a-chip systems present proof-of-concept studies, miniaturized organ systems still need to demonstrate translational relevance and predictive power in clinical and pharmaceutical settings. This review explores whether microfluidic technology succeeded in paving the way for developing physiologically relevant human in vitro models for pharmacology and toxicology in biomedical research within the last decade. Individual organ-on-a-chip systems are discussed, focusing on relevant applications and highlighting their ability to tackle current challenges in pharmacological research.
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