A New Electrochemical Platform for Dasatinib Anticancer Drug Sensing Using Fe3O4-SWCNTs/Ionic Liquid Paste Sensor

A new electrochemical platform was suggested for the sensing of the dasatinib (DA) anticancer drug based on paste electrode modification (PE) amplified with Fe3O4-SWCNTs nanocomposite and 1-hexyl-3-methylimidazolium tetrafluoroborate (mim-BF4-). The new platform showed a linear dynamic range from 0.001-220 mu M with a detection limit of 0.7 nM to determine DA at optimal condition. Electrochemical investigation showed that the redox reaction of DA is relative to changing the pH of solution. Moreover, Fe3O4-SWCNTs/mim-BF4-/PE has improved the oxidation current of DA about 5.58 times which reduced its oxidation potential by about 120 mV at optimal condition. In the final step, Fe3O4-SWCNTs/mim-BF4-/PE was used as an analytical platform to determine the DA in tablets and a dextrose saline spike sample, and the results showed recovery data 99.58-103.6% which confirm the powerful ability of the sensor as an analytical tool to determine the DA in real samples.

Automated summary

A new electrochemical platform was developed for the sensing of the anticancer drug dasatinib, with a linear dynamic range of 0.001-220 μM and a detection limit of 0.7 nM. The Fe3O4-SWCNTs/mim-BF4-/PE platform demonstrated enhanced oxidation current and reduced oxidation potential for the drug, with recovery rates for real samples ranging from 99.58-103.6%.