Journal
JOURNAL OF DIABETES RESEARCH
Volume 2021, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2021/6692695
Keywords
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Funding
- Key Clinical Specialty Development Project of Chongqing [2012143]
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The study identified factors associated with gestational diabetes mellitus (GDM), including maternal age ≥25 years, prepregnancy overweight or obese, family history of diabetes, history of GDM, macrosomia, stillbirth, premature delivery, pregestational smoking, and being primigravida.
Gestational diabetes mellitus (GDM) is a major public health issue, and the aim of the present study was to identify the factors associated with GDM. Databases were searched for observational studies until August 20, 2020. Pooled odds ratios (ORs) were calculated using fixed- or random-effects models. 103 studies involving 1,826,454 pregnant women were identified. Results indicated that maternalage >= 25 years (OR: 2.466, 95% CI: (2.121, 2.866)), prepregnancy overweight or obese (OR: 2.637, 95% CI: (1.561, 4.453)), family history of diabetes (FHD) (OR: 2.326, 95% CI: (1.904, 2.843)), history of GDM (OR: 21.137, 95% CI: (8.785, 50.858)), macrosomia (OR: 2.539, 95% CI: (1.612, 4.000)), stillbirth (OR: 2.341, 95% CI: (1.435, 3.819)), premature delivery (OR: 3.013, 95% CI: (1.569, 5.787)), and pregestational smoking (OR: 2.322, 95% CI: (1.359, 3.967)) increased the risk of GDM with all P<0.05, whereas history of congenital anomaly and abortion, and HIV status showed no correlation with GDM (P>0.05). Being primigravida (OR: 0.752, 95% CI: (0.698, 0.810), P<0.001) reduced the risk of GDM. The factors influencing GDM included maternalage25, prepregnancy overweight or obese, FHD, history of GDM, macrosomia, stillbirth, premature delivery, pregestational smoking, and primigravida.
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