Journal
FRONTIERS IN PLANT SCIENCE
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fpls.2021.662793
Keywords
COP1; SPA; CUL4; C3D; CDD; DDB1; E3 ligase; ubiquitination
Categories
Funding
- Deutsche Forschungsgemeinschaft (DFG) [HO2793/3-3]
- Deutsche Forschungsgemeinschaft (DFG) under Germany's Excellence Strategy [EXC 2048/1, 390686111]
Ask authors/readers for more resources
COP1 functions as an E3 ubiquitin ligase in plants and animals, serving as a central repressor of light-mediated responses in plants and a crucial regulator of tumorigenesis in humans. The recent research findings discussed in this review include a brief comparison of COP1 activity in plants and humans.
CONSTITUTIVE PHOTOMORPHOGENIC 1 functions as an E3 ubiquitin ligase in plants and animals. Discovered originally in Arabidopsis thaliana, COP1 acts in a complex with SPA proteins as a central repressor of light-mediated responses in plants. By ubiquitinating and promoting the degradation of several substrates, COP1/SPA regulates many aspects of plant growth, development and metabolism. In contrast to plants, human COP1 acts as a crucial regulator of tumorigenesis. In this review, we discuss the recent important findings in COP1/SPA research including a brief comparison between COP1 activity in plants and humans.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
