Journal
ACTA PSYCHIATRICA SCANDINAVICA
Volume 131, Issue 6, Pages 458-464Publisher
WILEY
DOI: 10.1111/acps.12397
Keywords
bipolar disorder; magnetic resonance imaging; affective disorders; staging
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Funding
- NIMH [R01 085667]
- Dunn Foundation
- Pat Rutherford, Jr. Endowed Chair in Psychiatry
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ObjectiveThis study investigated the differences in corpus callosum (CC) volumes between women with early-stage and late-stage bipolar I (BP I) disorder using the criteria previously described in the literature. MethodWe compared women with early- and late-stage BP I using criteria described in the Staging Systems Task Force Report of the International Society for Bipolar Disorders. We included 20 patients with early stage and 21 patients with late-stage BP I and a group of 25 healthy controls. Patients and controls underwent structural magnetic resonance imaging. Information on the clinical features of bipolar disorder was collected using a standardized questionnaire. Anatomical volumes of five regions of CC were compared between the three groups. ResultsWomen with late-stage BP I disorder had reduced posterior CC volumes compared with early-stage bipolar I patients and controls (F=6.05; P=0.004). The difference was significant after controlling for age, comorbidity with post-traumatic stress disorder, psychotic symptoms during mood episodes, and current use of medication. ConclusionThe posterior CC was significantly decreased in volume in women with late-stage bipolar disorder. These findings suggest that CC may be an anatomical target of neuroprogression in the course of bipolar disorder in women.
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