4.7 Review

Role and Mechanism of Gut Microbiota in Human Disease

Journal

Publisher

FRONTIERS MEDIA SA
DOI: 10.3389/fcimb.2021.625913

Keywords

gut microbiota; neurodegenerative diseases; cardiovascular diseases; metabolic diseases; gastrointestinal diseases

Funding

  1. National Natural Science Foundation of China [31701271]
  2. Natural Science Foundation of Zhejiang Province [LY21C110001]

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The human gut microbiome plays a crucial role in human health, and dysbiosis may lead to various chronic diseases. The mechanisms of its impact on neurodegenerative diseases, cardiovascular diseases, metabolic diseases, and gastrointestinal diseases are extremely complex.
The human gut microbiome is a huge microbial community that plays an irreplaceable role in human life. With the further development of research, the influence of intestinal flora on human diseases has been gradually excavated. Gut microbiota (GM) dysbiosis has adverse health effects on the human body that will lead to a variety of chronic diseases. The underlying mechanisms of GM on human diseases are incredibly complicated. This review focuses on the regulation and mechanism of GM on neurodegenerative diseases, cardiovascular diseases, metabolic diseases and gastrointestinal diseases, thus providing a potential target for the prevention and treatment of disease.

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