4.7 Review

Gut Microbiota and Diarrhea: An Updated Review

Journal

Publisher

FRONTIERS MEDIA SA
DOI: 10.3389/fcimb.2021.625210

Keywords

intestinal health; fecal microbiota transplantation; probiotics; gut microbiota; diarrhea

Funding

  1. Key Programs of frontier scientific research of the Chinese Academy of Sciences [QYZDY-SSW-SMC008]
  2. Young Elite Scientists Sponsorship Program by CAST [2019-2021QNRC001]
  3. Hunan Science Foundation for Outstanding Young Scholars [2020JJ3023]

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Diarrhea is closely linked to gut microbiota, and reshaping gut microbiota through dietary probiotics or fecal bacteria transplantation can help prevent or treat diarrhea.
Diarrhea is a common problem to the whole world and the occurrence of diarrhea is highly associated with gut microbiota, such as bacteria, fungi, and viruses. Generally, diarrheal patients or animals are characterized by gut microbiota dysbiosis and pathogen infections may lead to diarrheal phenotypes. Of relevance, reprograming gut microbiota communities by dietary probiotics or fecal bacteria transplantation are widely introduced to treat or prevent diarrhea. In this review, we discussed the influence of the gut microbiota in the infection of diarrhea pathogens, and updated the research of reshaping the gut microbiota to prevent or treat diarrhea for the past few years. Together, gut microbiota manipulation is of great significance to the prevention and treatment of diarrhea, and further insight into the function of the gut microbiota will help to discover more anti-diarrhea probiotics.

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