Journal
ASIAN JOURNAL OF ORGANIC CHEMISTRY
Volume 10, Issue 5, Pages 1102-1112Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.202100148
Keywords
Sulfonylphthalide; Isatylidenemalononitrile; Sulfonyloxindole; Tetramethylguanidine; Transfer sulfonation
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Funding
- SERB, DST India
- CSIR India
- IITB India
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The unusual reactivity of 3-sulfonylphthalides with isatylidenemalononitriles has been studied to provide an efficient entry into 3-sulfonyloxindoles, showing a mechanism involving Michael addition, elimination, and re-addition of functional groups. The synthetic applications of the sulfonyloxindoles in reactions such as conjugate addition and aromatization have also been demonstrated.
An unusual reactivity of 3-sulfonylphthalides with isatylidenemalononitriles has been exploited to provide an efficient entry into 3-sulfonyloxindoles. Although a Hauser-Kraus mechanism can be visualized for the observed transformation, a more probable mechanism, based on control experiments and spectroscopic studies, involves Michael addition of sulfonylphthalide to isatylidenemalononitrile followed by elimination and re-addition of sulfonyl and malononitrile functionalities in an overall functional group exchange between phthalide and oxindolyl moieties. We have also demonstrated the synthetic applications of the sulfonyloxindoles in selected reactions such as conjugate addition and aromatization.
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