Journal
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
Volume 55, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.algal.2021.102277
Keywords
Biosynthesis; Cyanobacteria; Harmful algae blooms; Microcystins; Toxic effect
Categories
Funding
- National Key Research and Development Program of China [2018YFA0903100]
- National Natural Science Foundation of China [91851103, 31870041, 31770128]
- Natural Science Foundation of Henan [212300410024]
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The increase in population growth and associated pressures on agricultural, urban, and industrial development has led to a rise in harmful algal blooms. Microcystins produced by various cyanobacteria can be toxic to both humans and animals. This review article summarizes the understanding of microcystin biosynthesis and its effects on surrounding organisms, proposing directions for further research in this field.
Population growth and its associated pressure on agricultural, urban, and industrial development have increased the incidence of harmful algal blooms. Microcystins are toxins produced by a variety of bloom-forming cyanobacteria that can cause hepatotoxicity in humans and animals. In this review article, we summarize progress in the understanding of microcystin biosynthesis and the effects of this toxin on surrounding organisms. We also present possible directions for further understanding the basic biology of microcystin biosynthesis. In particular, heterologous synthesis of microcystins in model cyanobacteria based on photosynthesis through the synthetic biology techniques will be an important step towards clarifying how microcystins are produced, how their synthesis is regulated, and how toxicity is produced in neighboring photosynthetic algae. The information presented here serves as a reference both for algal researchers and policymakers involved in setting future directions in microalgal research, particularly pertaining to microalgal-based microcystin biosynthesis.
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