Journal
TRANSLATIONAL STROKE RESEARCH
Volume 13, Issue 1, Pages 171-187Publisher
SPRINGER
DOI: 10.1007/s12975-021-00915-3
Keywords
Application; Extracellular vesicles; Ischemic stroke; Mechanisms; Therapeutic effects
Categories
Funding
- Science and Technology Development Fund of Macau (FDCT) [0093/2018/A3, 0106/2019/A2]
- National Natural Science Foundation of China (NSFC) [82074051]
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EVs have shown significant beneficial effects on ischemic stroke, easily penetrating the blood-brain barrier and migrating into the brain, offering new potential for IS treatment.
Ischemic stroke (IS) accounts for most of the cases of stroke onset, and due to short therapeutic time window for thrombolysis and numerous limited treatment measures and contraindications, lots of patients cannot receive satisfying therapeutic effects resulting in high disability and mortality worldly. In recent years, extracellular vesicles (EVs), as nanosized membrane-structured vesicles secreted from almost all cells, especially from stem/progenitor cells, have been reported to exert significant beneficial effects on IS from multiple approaches and notably ameliorate neurological outcome. Moreover, based on nano-size and lipid bilayer structure, EVs can easily penetrate the blood-brain barrier and migrate into the brain. In this review, we mainly systematically summarize the therapeutic effects of EVs on IS and explore their potential applications. Simultaneously, we also discuss administration routines, dosages, experimental observation time, and some key issues of EV application during IS treatment. It contributes to a comprehensive understanding of the progress of EV treatment for IS and providing confident evidence for further EV clinical application widely.
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