Journal
TOXINS
Volume 13, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/toxins13050338
Keywords
cobra; snakebites; tissue necrosis; venom; antivenom
Categories
Ask authors/readers for more resources
Local tissue swelling, inflammation, and wound necrosis are observed in Taiwan cobra bites, with factors like initial limb swelling, presentation time x serum level, initial necrosis, and patient presentation time influencing wound necrosis. Serum venom level alone cannot predict tissue necrosis, suggesting the importance of considering venom and time factors in future studies on antivenom efficacy.
Local tissue swelling, inflammation, and wound necrosis are observed in Taiwan cobra bites. Knowledge of the factors influencing local tissue necrosis after cobra bites might improve the cobra bite treatment strategy. Therefore, we aimed to explore the factors influencing local tissue necrosis after cobra bites. This was a retrospective observational cohort study. All patients clinical presentations including serum venom levels for determining the influential factors in this study were obtained from Hung et al.'s previous study. Clinical features, such as bite information, initial swelling, patient presentation time, serum venom levels, and antivenom, use were extracted. The measurement outcome was the development of wound necrosis. The factors influencing wound necrosis were investigated using univariate and logistic regression analyses. The influential factors of local tissue necrosis and their areas under the curve were: initial limb swelling, 0.88; presentation time x serum level, 0.80; initial necrosis, 0.75; patient presentation time, 0.70. Serum venom level alone cannot be used as a predictive factor. The development of tissue necrosis might be associated with the venom factor, time factor, and their interaction. These influential factors can be used in future studies to evaluate antivenom efficacy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available