Journal
POLYMERS
Volume 13, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/polym13081228
Keywords
thermo-responsive graft copolymer; alginate; PNIPAM; thermo-thickening; shear thinning injectability; organic; inorganic hybrid; mesoporous silica; LbL technique; hydrogel composite
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Mesoporous silica nanoparticles covered with layer-by-layer oppositely charged weak polyelectrolytes were prepared, exhibiting pH/thermo-responsive drug delivery capabilities. The release kinetics of model drug rhodamine B could be controlled by the number of bilayers and environmental conditions. A composite hydrogel encapsulating these nanoparticles showed sustainable drug delivery properties, indicating potential for biomedical applications.
We report the preparation of mesoporous silica nanoparticles covered by layer by layer (LbL) oppositely charged weak polyelectrolytes, comprising poly(allylamine hydrochloride) (PAH) and a sodium alginate, highly grafted by N-isopropylacrylamide/N-tert-butylacrylamide random copolymers, NaALG-g-P(NIPAM(90)-co-NtBAM(10)) (NaALG-g). Thanks to the pH dependence of the degree of ionization of the polyelectrolytes and the LCST-type thermosensitivity of the grafting chains of the NaALG-g, the as-prepared hybrid nanoparticles (hNP) exhibit pH/thermo-responsive drug delivery capabilities. The release kinetics of rhodamine B (RB, model drug) can be controlled by the number of PAH/NaALG-g bilayers and more importantly by the environmental conditions, namely, pH and temperature. As observed, the increase of pH and/or temperature accelerates the RB release under sink conditions. The same NaALG-g was used as gelator to fabricate a hNP@NaALG-g hydrogel composite. This formulation forms a viscous solution at room temperature, and it is transformed to a self-assembling hydrogel (sol-gel transition) upon heating at physiological temperature provided that its T-gel was regulated at 30.7 degrees C, by the NtBAM hydrophobic monomer incorporation in the side chains. It exhibits excellent injectability thanks to its combined thermo- and shear-responsiveness. The hNP@NaALG-g hydrogel composite, encapsulating hNP covered with one bilayer, exhibited pH-responsive sustainable drug delivery. The presented highly tunable drug delivery system (DDS) (hNP and/or composite hydrogel) might be useful for biomedical potential applications.
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