Serological evidence of single and mixed infections of Rift Valley fever virus, Brucella spp. and Coxiella burnetii in dromedary camels in Kenya

Author summary Dromedary camels are well adapted to the arid and semi-arid environment that makes up about 80% of Kenya's landmass. As such, camels play an important role in the socio-economic wellbeing and food security of pastoralists in the country. However, the species remains relatively neglected in scientific research, one of the main reasons being camels are mostly found in remote, low-income, arid regions of Africa and Asia. We carried out a study to determine the levels of exposure of camels in northern Kenya to Brucella spp., Coxiella burnetii and Rift Valley fever virus, three priority zoonotic pathogens in the country. We found high levels of exposure to the three pathogens, indicating the important role camels might play in the epidemiology of the zoonotic diseases in humans and other livestock. Based on the study findings, we argue for the immediate need for investments in disease surveillance and control strategies for priority zoonotic disease in camels in Kenya. Camels are increasingly becoming the livestock of choice for pastoralists reeling from effects of climate change in semi-arid and arid parts of Kenya. As the population of camels rises, better understanding of their role in the epidemiology of zoonotic diseases in Kenya is a public health priority. Rift Valley fever (RVF), brucellosis and Q fever are three of the top priority diseases in the country but the involvement of camels in the transmission dynamics of these diseases is poorly understood. We analyzed 120 camel serum samples from northern Kenya to establish seropositivity rates of the three pathogens and to characterize the infecting Brucella species using molecular assays. We found seropositivity of 24.2% (95% confidence interval [CI]: 16.5-31.8%) for Brucella, 20.8% (95% CI: 13.6-28.1%) and 14.2% (95% CI: 7.9-20.4%) for Coxiella burnetii and Rift valley fever virus respectively. We found 27.5% (95% CI: 19.5-35.5%) of the animals were seropositive for at least one pathogen and 13.3% (95% CI: 7.2-19.4%) were seropositive for at least two pathogens. B. melitensis was the only Brucella spp. detected. The high sero-positivity rates are indicative of the endemicity of these pathogens among camel populations and the possible role the species has in the epidemiology of zoonotic diseases. Considering the strong association between human infection and contact with livestock for most zoonotic infections in Kenya, there is immediate need to conduct further research to determine the role of camels in transmission of these zoonoses to other livestock species and humans. This information will be useful for designing more effective surveillance systems and intervention measures.

Automated summary

The study found high levels of exposure of northern Kenyan camels to zoonotic pathogens, highlighting their importance in disease epidemiology. Immediate investments in disease surveillance and control strategies are necessary, along with further research into the role of camels in zoonotic disease transmission.