Journal
JOURNAL OF PARKINSONS DISEASE
Volume 11, Issue 3, Pages 937-947Publisher
IOS PRESS
DOI: 10.3233/JPD-202489
Keywords
Parkinson's disease; synucleinopathy; skin; alpha-synuclein
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Skin biopsies can serve as a potential diagnostic tool for Parkinson's disease and other synucleinopathies, with important implications for pre-mortem histopathological confirmation and clinical research targeting alpha-synuclein aggregates.
Alpha-synuclein deposits are detectable in skin biopsies of patients with Parkinson's disease and other synucleinopathies like multiple system atrophy by immunohistochemical staining. As they are easily to obtain, they appear a promising tool for the pre-mortem histopathological confirmation of the disease and as a potential outcome measure in studies targeting alpha-synuclein aggregates. Good sensitivity, specificity, and practicability are the most important requirements of a biomarker. The review gives an overview on all three aspects, addresses methodological problems and the lack of standardized procedures as a major problem and gives an outlook on the future of skin biopsy as a potential diagnostic tool in synucleinopathies.
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