Journal
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
Volume 18, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/ijerph18095010
Keywords
metabolic syndrome; central obesity; depression; high sensitivity C-reactive protein; intracellular adhesion molecule-1; Bogalusa heart study
Funding
- National Institutes of Health, NIH [G12MD007581, U54MD015929, P20MD006899, HHSN268201800013I]
- National Institute on Aging (NIH) [AG016592]
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This study found that in White young adults, depression symptoms influenced central obesity through high-sensitivity C-reactive protein mediation, but did not have a direct impact on metabolic syndrome itself.
This study examined the association between depression symptoms and metabolic syndrome (MetS) or its components prospectively. It assessed the mediator role of high-sensitivity C-reactive protein (hs-CRP) and intracellular adhesion molecule-1 (ICAM-1). Self-reported depression symptoms were assessed using the Center for Epidemiologic Studies-Depression scale. MetS was defined as having at least three of the following five criteria: (1) waist circumference >102 centimeters (cm) in men or >88 cm in women; (2) triglycerides >= 50 milligrams per deciliter (mg/dL); (3) high-density lipoprotein cholesterol <40 mg/dL in men or <50 mg/dL in women; (4) blood pressure: systolic >= 30 and diastolic >= 85 mm of mercury or on antihypertensive medication; and (5) fasting glucose >= 110 mg/dL. The risk ratios (RR) with 95% confidence interval (CI) were estimated using multivariate Poisson regression models. A total of 419 White and 180 Black individuals with a mean age of 36 years were followed for 6.9 years. The findings demonstrated that hs-CRP mediated the influence of depression symptoms on central obesity in White young adults. The adjusted RR for central obesity was 1.08 with 95% CI of 0.88-1.32, and the value for hs-CRP was 1.12 with 95% CI of 1.02-1.23. Although depression did not influence MetS in this study cohort, the complete mediator role of hs-CRP was established for central obesity, a component of MetS in White young adults.
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