Journal
HUMAN VACCINES & IMMUNOTHERAPEUTICS
Volume 17, Issue 8, Pages 2378-2388Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/21645515.2021.1892432
Keywords
COVID-19; pregnant women; vaccine; acceptance; vaccine hesitancy
Categories
Funding
- National Key Research and Development Project of China [2020YFC0846300, 2019YFC1710301]
- National Science and Technology Key Projects on Prevention and Treatment of Major infectious disease of China [2020ZX10001002]
- National Natural Science Foundation of China [71874003, 81703240]
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The study found that there is vaccine hesitancy among pregnant women, and acceptance rate is related to factors such as age, region, education level, pregnancy stage, knowledge on COVID-19, perceived susceptibility, perceived barriers, etc. Targeted efforts are needed to increase vaccine acceptance among vulnerable populations during the COVID-19 pandemic.
Background: Vaccine hesitancy has been recognized as an urgent public health issue. We aimed to explore the acceptance of a COVID-19 vaccine and related factors among pregnant women, a vulnerable population for vaccine-preventable diseases. Methods: A multi-center cross-sectional study among pregnant women was conducted in five provinces of mainland China from November 13 to 27, 2020. We collected sociodemographic characteristics, attitude, knowledge, and health beliefs on COVID-19 vaccination. Locally weighted scatterplot smoothing regression analysis was used to assess the trends of vaccination acceptance. Multivariable logistic regression was performed to identify factors related to vaccination acceptance. Results: Among the 1392 pregnant women, the acceptance rate of a COVID-19 vaccine were 77.4% (95%CI 75.1-79.5%). In the multivariable regression model, the acceptance rate was associated with young age (aOR = 1.87, 95% CI: 1.20-2.93), western region (aOR = 2.73, 95% CI: 1.72-4.32), low level of education (aOR = 2.49, 95% CI: 1.13-5.51), late pregnancy (aOR = 1.49, 95% CI: 1.03-2.16), high knowledge score on COVID-19 (aOR = 1.05, 95% CI: 1.01-1.10), high level of perceived susceptibility (aOR = 2.18, 95% CI: 1.36-3.49), low level of perceived barriers (aOR = 4.76, 95% CI: 2.23-10.18), high level of perceived benefit (aOR = 2.18, 95% CI: 1.36-3.49), and high level of perceived cues to action (aOR = 15.70, 95% CI: 8.28-29.80). Conclusions: About one quarters of pregnant women have vaccine hesitancy. Our findings highlight that targeted and multipronged efforts are needed to build vaccine literacy and confidence to increase the acceptance of a COVID-19 vaccine during the COVID-19 pandemic, especially for vulnerable populations.
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