Journal
ADVANCED HEALTHCARE MATERIALS
Volume 10, Issue 11, Pages -Publisher
WILEY
DOI: 10.1002/adhm.202001974
Keywords
anticancer therapy; nanomedicines; polymer– drug conjugates; polypeptides; prodrugs
Funding
- National Natural Science Foundation of China [52003268, 51803014, 51833010, 51803209]
- Jilin Provincial Science and Technology Development Program [20190103038JH, 20200801006GH, 20190103022JH]
- Youth Innovation Promotion Association of Chinese Academy of Sciences [2017266]
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Polypeptides are important biodegradable polymers widely used in drug delivery for cancer treatment. Conjugating anticancer drugs with polypeptides offers advantages in improving pharmacokinetics, enhancing targeting, and controlling drug release, contributing to enhanced therapeutic outcomes with reduced side effects.
Polypeptides are an important class of biodegradable polymers that have been widely used in drug delivery field. Owing to the controllable synthesis and robust side chain-functionalization ability, polypeptides have long been ideal candidates for conjugation with anticancer drugs. The chemical conjugation of anticancer drugs with polypeptides, termed polypeptides-drug conjugates, has demonstrated several advantages in improving pharmacokinetics, enhancing drug targeting, and controlling drug release, thereby leading to enhanced therapeutic outcomes with reduced side toxicities. This review focuses on the recent advances in the design and preparation of polypeptides-drug conjugates for enhanced anticancer therapy. Strategies for conjugation of different types of drugs, including small-molecule chemotherapeutic drugs, proteins, vascular disrupting agents, and gas molecules, onto polypeptides backbone are summarized. Finally, the challenges and future perspectives on the development of innovative polypeptides-drug conjugates for clinical cancer treatment are also presented.
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