Journal
ADVANCED HEALTHCARE MATERIALS
Volume 10, Issue 12, Pages -Publisher
WILEY
DOI: 10.1002/adhm.202100090
Keywords
anti‐ tumor immunity; nanozymes; NIR‐ II imaging; quantum dot s; radiotherapy
Funding
- National Natural Science Foundation of China [21974104, 51873168, 81874131]
- National Key Research and Development Program [2017YFSF090107]
Ask authors/readers for more resources
A new type of nanozyme has been developed for tumor-targeted radiotherapy, which is constructed as in vivo nanoprobes guided by NIR-II imaging. These nanoprobes exhibit high stability in vivo and continuous oxygen generation to relieve tumor hypoxia, enhancing the efficacy of radiotherapy.
Currently, radiotherapy (RT) is the main method for cancer treatment. However, the hypoxic environment of solid tumors is likely to cause resistance or failure of RT. Moreover, high-dose radiation may cause side effects to surrounding normal tissues. In this study, a new type of nanozyme is developed by doping Mn (II) ions into Ag2Se quantum dots (QDs) emitting in the second near-infrared window (NIR-II, 1000-1700 nm). Through the catalysis of Mn (II) ions, the nanozymes can trigger the rapid decomposition of H2O2 and produce O-2. Conjugated with tumor-targeting arginine-glycine-aspartate (RGD) tripeptides and polyethylene glycol (PEG) molecules, the nanozymes are then constructed into in vivo nanoprobes for NIR-II imaging-guided RT of tumors. Owing to the radiosensitive activity of the element Ag, the nanoprobes can promote radiation energy deposition. The specific tumor-targeting and NIR-II emitting abilities of the nanoprobes facilitate the precise tumor localization, which enables precise RT with low side effects. Moreover, their ultra-stability in the living body ensures that the nanoprobes continuously produce oxygen and relieve the hypoxia of tumors to enhance RT efficacy. Guided by real-time and high-clarity imaging, the nanoprobe-mediated RT promotes anti-tumor immunity, which significantly inhibits the growth of tumors or even cures them completely.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available