Journal
ADVANCED HEALTHCARE MATERIALS
Volume 10, Issue 9, Pages -Publisher
WILEY
DOI: 10.1002/adhm.202002115
Keywords
croconaine; nanoparticles; optoacoustics; photothermal therapy
Funding
- European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme [694968]
- Deutsche Forschungsgemeinschaft (DFG), Germany [NT 3/10-1]
- DFG [CRC 1123]
- China Scholarship Council
- Helmholtz Association
- BMBF [16GW0251K]
- Projekt DEAL
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This study introduces the use of CR760 for nanoparticle formulation, optoacoustic imaging, and photothermal therapy. CR760 exhibits excellent optical properties, can be conveniently prepared in a single step, and can be covalently attached to cancer-targeting ligands to form nanoparticles with active tumor-targeting capability.
Near-infrared (NIR) light absorbing theranostic agents can integrate optoacoustic imaging and photothermal therapy for effective personalized precision medicine. However, most of these agents face the challenges of unstable optical properties, material-associated toxicity, and nonbiodegradability, all of which limit their biomedical application. Several croconaine-based organic agents able to overcome some of these limitations have been recently reported, but these suffer from complicated multistep synthesis protocols. Herein, the use of CR760, a croconaine dye with excellent optical properties, is reported for nanoparticle formulation and subsequent optoacoustic imaging and photothermal therapy. Importantly, CR760 can be conveniently prepared in a single step from commercially available materials. Furthermore, CR760 can be covalently attached, via a polyethylene glycol linker, to the alpha(v)beta(3) integrin ligand c(RGDyC), resulting in self-assembled nanoparticles (NPs) with cancer-targeting capability. Such CR760RGD-NPs exhibit strong NIR absorption, high photostability, high optoacoustic generation efficiency, and active tumor-targeting, making them ideal candidates for optoacoustic imaging. Due to favorable electron transfer, CR760RGD-NPs display a 45.37% photothermal conversion efficiency thereby rendering them additionally useful for photothermal therapy. Targeted tumor elimination, biosafety, and biocompatibility are demonstrated in a 4T1 murine breast tumor model. This work points to the use of CR760RGD-NPs as a promising nanoagent for NIR-based cancer phototheranostics.
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