Prognostic Biomarker ZNF311 and Its Correlation With Tumor Progression and Immune Infiltrates in Glioma

-BACKGROUND: Gliomas, particularly high-grade gli-omas, are the most common primary brain tumors. From the Chinese Glioma Genome Atlas (CGGA) database, the re-lationships between the altered molecular pathways and gliomas could be easily observed. A close connection in the occurrence of the pathogenesis exists between the microenvironment, the glioma, and the associated genes. - METHODS: Validation of the role of ZNF311 oncogene was confirmed by data from the CGGA dataset on glio-blastoma and low-grade glioma. Furthermore, we used CIBERSORT to analyze the correlation between ZNF311 and cancer immune infiltrates. - RESULTS: According to our analysis, ZNF311 was expressed higher in patients with grade-depended glioma with poor prognosis. In addition, we obtained valuable prognostic results between isocitrate dehydrogenase 1 (IDH1) and ZNF311 through the analysis of integrated cor -relations. Similarly, we simultaneously revealed the prog-nostic results between 1p/19q and ZNF311. In addition, we found that ZNF311 is correlated with a large number of tumor-infiltrating immune cells. - CONCLUSIONS: Based on the study findings, we conclude that ZNF311 is potentially a novel biomarker for assessing prognosis and immune infiltration in glioblas-toma and diffuse glioma cases. - RESULTS: According to our analysis, ZNF311 was expressed higher in patients with grade-depended glioma with poor prognosis. In addition, we obtained valuable prognostic results between isocitrate dehydrogenase 1 (IDH1) and ZNF311 through the analysis of integrated correlations. Similarly, we simultaneously revealed the prognostic results between 1p/19q and ZNF311. In addition, we found that ZNF311 is correlated with a large number of tumor-infiltrating immune cells. - CONCLUSIONS: Based on the study findings, we conclude that ZNF311 is potentially a novel biomarker for assessing prognosis and immune infiltration in glioblas

Automated summary

ZNF311 oncogene is closely related to prognosis and immune infiltration in gliomas, making it a potential novel biomarker for assessment. The study findings suggest significant correlations between ZNF311, IDH1, 1p/19q, and tumor-infiltrating immune cells in glioma patients with poor prognosis.