Journal
SCIENTIFIC REPORTS
Volume 11, Issue 1, Pages -Publisher
NATURE RESEARCH
DOI: 10.1038/s41598-021-88870-9
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [19K16503]
- Translational Research program, Strategic PRomotion for practical application of INnovative medical Technology (TR-SPRINT) - Japan Agency for Medical Research and Development
- Grants-in-Aid for Scientific Research [19K16503] Funding Source: KAKEN
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Dietary intake of c-9, t-11-CLA showed positive effects on an Alzheimer's disease mouse model, including decreasing amyloid-beta levels and suppressing inflammation.
Conjugated linoleic acid (CLA) is an isomer of linoleic acid (LA). The predominant dietary CLA is cis-9, trans-11-CLA (c-9, t-11-CLA), which constitutes up to similar to 90% of total CLA and is thought to be responsible for the positive health benefits associated with CLA. However, the effects of c-9, t-11-CLA on Alzheimer's disease (AD) remain to be elucidated. In this study, we investigated the effect of dietary intake of c-9, t-11-CLA on the pathogenesis of an AD mouse model. We found that c-9, t-11-CLA diet-fed AD model mice significantly exhibited (1) a decrease in amyloid-beta protein (A beta) levels in the hippocampus, (2) an increase in the number of microglia, and (3) an increase in the number of astrocytes expressing the anti-inflammatory cytokines, interleukin-10 and 19 (IL10, IL-19), with no change in the total number of astrocytes. In addition, liquid chromatographytandem mass spectrometry (LC-MS/MS) and gas chromatographic analysis revealed that the levels of lysophosphatidylcholine (LPC) containing c-9, t-11-CLA (CLA-LPC) and free c-9, t-11-CLA were significantly increased in the brain of c-9, t-11-CLA diet-fed mice. Thus, dietary c-9, t-11-CLA entered the brain and appeared to exhibit beneficial effects on AD, including a decrease in A beta levels and suppression of inflammation.
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