A unified resource and configurable model of the synapse proteome and its role in disease

Genes encoding synaptic proteins are highly associated with neuronal disorders many of which show clinical co-morbidity. We integrated 58 published synaptic proteomic datasets that describe over 8000 proteins and combined them with direct protein-protein interactions and functional metadata to build a network resource that reveals the shared and unique protein components that underpin multiple disorders. All the data are provided in a flexible and accessible format to encourage custom use.

Automated summary

Genes encoding synaptic proteins are highly linked to neuronal disorders with clinical co-morbidities. By integrating 58 published synaptic proteomic datasets, we built a network resource containing over 8000 proteins, revealing shared and unique protein components underlying multiple disorders. The data are provided in a flexible and accessible format for custom use.