Journal
EUROPEAN JOURNAL OF RADIOLOGY
Volume 85, Issue 6, Pages 1053-1057Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ejrad.2016.03.011
Keywords
Breast cancer; Chemotherapy; Cognitive impairment; Functional connectivity; Functional MRI
Funding
- National Science Foundation of China [81371537, 91432301]
- Major State Basic Research Development Program of China (973 Program) [2013CB733803]
- Fundamental Research Funds for the Central Universities of China [WK2070000033]
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Background: Chemotherapy, a prominent treatment for breast cancer (BC), can have detrimental side effects on the patient's cognitive functions including the executive function. However, the neurophysiological mechanism of the cognitive impairment remains unclear. Objective: The purpose of this study is to explore long-term chemotherapy-related functional connectivity changes using fMRI and the relationship between the connectivity changes and the executive function impairment in breast cancer patients. Methods: In this study, twenty-three breast cancer patients were treated with chemotherapy and twenty-six healthy subjects were recruited as the healthy control (HC) group. The functional connectivity of anterior cingulate cortex (ACC) was calculated from resting-state fMRI of the BC and control groups. The relationship between the functional connectivity of ACC and the executive function was further analyzed based on the patient' response time of the Stroop Interference Test. Results: The results show that functional connectivity of ACC in the BC group is significantly lower than that in the control group. The correlation analysis within the BC group indicates that the functional connectivity of ACC was significantly correlated with the executive function. Conclusion: These findings provide evidence that the functional connectivity changes might be a pathophysiological basis for long-term chemotherapy-related cognitive dysfunction, along with executive function impairment in breast cancer patients. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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