Diagnostic performance and characteristics of anterior nasal collection for the SARS-CoV-2 antigen test: a prospective study

Article Infectious Diseases

Clinical validation of quantitative SARS-CoV-2 antigen assays to estimate SARS-CoV-2 viral loads in nasopharyngeal swabs

Kotaro Aoki et al.

Summary: The study found that Lumipulse (R) SARS-CoV-2 Ag has high concordance with RT-PCR for SARS-CoV-2 and can be used for the diagnosis of COVID-19 in any clinical setting. Therefore, this fully automated chemiluminescent enzyme immunoassay system will contribute to the expansion of testing capability for SARS-CoV-2.

JOURNAL OF INFECTION AND CHEMOTHERAPY (2021)

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Article Infectious Diseases

Multicenter evaluation of the Panbio™ COVID-19 rapid antigen-detection test for the diagnosis of SARS-CoV-2 infection

Paloma Merino et al.

Summary: The study aimed to evaluate the performance of the PanbioRT COVID-19 Ag Rapid Test Device in detecting SARS-CoV-2 in patients with COVID-19 symptoms. The results showed that PanbioRT performed well clinically, especially for patients with a shorter clinical course or a higher viral load.

CLINICAL MICROBIOLOGY AND INFECTION (2021)

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Article Infectious Diseases

The evaluation of a newly developed antigen test (QuickNaviTM-COVID19 Ag) for SARS-CoV-2: A prospective observational study in Japan

Yuto Takeuchi et al.

Summary: In this study, the newly developed QuickNaviTM-COVID19 Ag antigen test in Japan showed high specificity and sufficient sensitivity for detecting SARS-CoV-2. The test performed well, especially in symptomatic patients.

JOURNAL OF INFECTION AND CHEMOTHERAPY (2021)

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Article Infectious Diseases

Prospective study of 1308 nasopharyngeal swabs from 1033 patients using the LUMIPULSE SARS-CoV-2 antigen test: Comparison with RT-qPCR

Yosuke Hirotsu et al.

Summary: This prospective study demonstrated that the LUMIPULSE antigen test is highly accurate for SARS-CoV-2 detection, showing high sensitivity and specificity, particularly in diagnosing the disease accurately in the late phase of infection.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

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Review Infectious Diseases

Diagnostic performance of different sampling approaches for SARS-CoV-2 RT-PCR testing: a systematic review and meta-analysis

Nicole Ngai Yung Tsang et al.

Summary: This study systematically compared the diagnostic performance of different clinical specimen collection methods for SARS-CoV-2 infection. Pooled nasal and throat swabs showed the highest sensitivity and positive predictive value, while saliva and nasal swabs also demonstrated good diagnostic performance. Throat swabs had a significantly lower sensitivity and positive predictive value and were not recommended for diagnosis. Self-collection for pooled nasal and throat swabs and nasal swabs did not affect diagnostic accuracy.

LANCET INFECTIOUS DISEASES (2021)

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Article Medicine, General & Internal

Clinical assessment of the Roche SARS-CoV-2 rapid antigen test

Gian Luca Salvagno et al.

Summary: The study assessed the clinical performance of the Roche SARS-CoV-2 Rapid Antigen Test and found that it has excellent accuracy and sensitivity in nasopharyngeal swabs with Ct values <25, making it reliable for screening patients with high viral load. However, more sensitive techniques would be needed for mass community screening.

DIAGNOSIS (2021)

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Letter Microbiology