Journal
NUTRIENTS
Volume 13, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/nu13051479
Keywords
irritable bowel syndrome; microbiota; dietary habits; nutrient intake; Mediterranean diet
Categories
Funding
- Ministry of Health (Ministero della Salute), Italy [WFR GR-2011-02350817]
- RC Ministry of Health (Ministero della Salute), Italy [201905_genetica_putignani]
Ask authors/readers for more resources
This study revealed an association between nutrient intake, adherence to Mediterranean diet, IBS symptoms, and gut microbiota in IBS patients. Lower adherence to Mediterranean diet was correlated with severe abdominal pain and higher flatulence in IBS patients, indicating a potential connection between dietary patterns and gut microbial biomarkers in IBS.
Intestinal dysbiosis seems to play a role in the pathophysiology of irritable bowel syndrome (IBS). The present pilot study aimed to elucidate the association between nutrient intake and Mediterranean diet (MD) adherence with IBS symptoms and gut microbiota in IBS patients. The nutrient intake of 28 IBS patients and 21 controls was assessed through a food diary, the reference intake ranges (RIs) for energy-yielding macronutrients and the MD serving score (MDSS) index. MD adherence and nutrients intake were compared to IBS symptoms and fecal microbiota, obtained by 16S rRNA targeted-metagenomics. In IBS patients MDSS index was altered compared to controls (p < 0.01). IBS patients with low-MD score reported severe abdominal pain and higher flatulence point-scales. Through Linear discriminant analysis effect size (LEfSe), Erysipelotrichaceae were detected as a microbial biomarker in IBS patients with altered RIs for macronutrients intake, compared to controls. Lactobacillaceae and Lactobacillus were associated to an altered carbohydrates intake in IBS patients, while specific taxonomic biomarkers, such as Aldercreuzia, Mogibacteriaceae, Rikenellaceae, Parabacteroides and F. prausnitzii were associated with an adequate intake of nutrient in these patients. This study supports an association between dietary patterns and gut microbial biomarkers in IBS patients. Further investigations are needed to clarify these connections.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available