Journal
NUTRIENTS
Volume 13, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/nu13041148
Keywords
vitamin D; C-reactive protein; saliva; oral inflammation; periodontal diseases; epidemiology
Categories
Funding
- NIH [1R21DE020918, 1R01DE13505, 1RC1DE020404]
- National Institute of Dental and Craniofacial Research (NIDCR)
- Department of Defense [DAMD179616319]
- National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services [HHSN268201600018C, HHSN268201600001C, HHSN268201600002C, HHSN268201600003C, HHSN268201600004C]
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The study found a negative association between plasma 25-hydroxyvitamin D (25[OH]D) concentrations and salivary CRP concentrations in postmenopausal women, which attenuated after adjusting for other factors. However, there was no significant association between 25[OH]D and serum CRP concentrations.
Vitamin D has been hypothesized to play an important role in preventing the development and progression of periodontal disease, but the underlying immune modulatory mechanisms remain understudied. We examined the cross-sectional association between biomarkers of vitamin D status and C-reactive protein (CRP) among postmenopausal women aged 53-81 years. Linear regression was used to examine the association between plasma 25-hydroxyvitamin D (25[OH]D) concentrations, a biomarker of vitamin D status, and both salivary and serum CRP concentrations in 567 women from the Buffalo Osteoporosis and Periodontal Disease (OsteoPerio) Study (1997-2000). CRP concentrations were measured with multiplex arrays and transformed for normality using the natural log. Concentrations above and below the limit of detection were included in analysis as right- and left-censored observations. An inverse association was observed between 25(OH)D and salivary CRP in a model adjusted for age, smoking status, frequency of tooth brushing and flossing, and hormone therapy use (-7.56% difference in salivary CRP concentrations per 10 nmol/L increase in 25(OH)D, 95% CI: -12.78 to -2.03). Further adjustment for percent body fat attenuated this association (-2.48%, 95% CI: -7.88 to 3.24). No significant associations were found between 25(OH)D and serum CRP. Plasma vitamin D concentrations were not associated with salivary or serum CRP concentrations in this cohort of postmenopausal women.
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