Journal
NUTRIENTS
Volume 13, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/nu13041090
Keywords
atopic dermatitis; β ‐ glucan; house dust mite; Nc; Nga mice; probiotics
Categories
Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science [NRF-2020R1F1A1073007]
- Cooperative Research Program for Agriculture Science and Technology Development, Rural Development Administration, Republic of Korea [PJ01395602]
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The study demonstrated that beta-glucan extracted from oats and fermented probiotic mixture is effective in treating atopic dermatitis. The mixture could alleviate skin lesions and regulate immune response-related genes in a mouse model of AD.
Many trials have been conducted to treat atopic dermatitis (AD), but these therapies are generally unsuccessful because of their insufficiency or side effects. This study examined the efficacy of beta-glucan derived from oats with fermented probiotics (called Synbio-glucan) on an AD-induced mouse model. For the experiment, Nc/Nga mice were exposed to a house dust mite extract (HDM) to induce AD. The mice were placed in one of four groups: positive control group, Synbio-glucan topical treatment group, Synbio-glucan dietary treatment group, and Synbio-glucan topical + dietary treatment group. The experiment revealed no significant difference in the serum IgE concentration among the groups. Serum cytokine antibody arrays showed that genes related to the immune response were enriched. A significant difference in the skin lesion scores was observed between the groups. Compared to the control group tissue, skin lesions were alleviated in the Synbio-glucan topical treatment group and Synbio-glucan dietary treatment group. Interestingly, almost normal structures were observed within the skin lesions in the Synbio-glucan topical + dietary treatment group. Overall, the beta-glucan extracted from oats and fermented probiotic mixture is effective in treating atopic dermatitis.
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