Journal
MATERIALS
Volume 14, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/ma14071802
Keywords
stimuli-responsive hydrogel; intranasal administration; nose to brain; neurodegenerative diseases; Alzheimer’ s disease; Parkinson’ s disease; drug delivery
Ask authors/readers for more resources
Neurological diseases have become a global health issue in recent years, with limitations in current therapeutic approaches due to the blood-brain barrier. The intranasal route has emerged as a promising method for delivering drugs to the central nervous system, bypassing the blood-brain barrier and increasing drug bioavailability.
In the last years, neurological diseases have resulted in a global health issue, representing the first cause of disability worldwide. Current therapeutic approaches against neurological disorders include oral, topical, or intravenous administration of drugs and more invasive techniques such as surgery and brain implants. Unfortunately, at present, there are no fully effective treatments against neurodegenerative diseases, because they are not associated with a regeneration of the neural tissue but rather act on slowing the neurodegenerative process. The main limitation of central nervous system therapeutics is related to their delivery to the nervous system in therapeutic quantities due to the presence of the blood-brain barrier. In this regard, recently, the intranasal route has emerged as a promising administration site for central nervous system therapeutics since it provides a direct connection to the central nervous system, avoiding the passage through the blood-brain barrier, consequently increasing drug cerebral bioavailability. This review provides an overview of the nose-to-brain route: first, we summarize the anatomy of this route, focusing on the neural mechanisms responsible for the delivery of central nervous system therapeutics to the brain, and then we discuss the recent advances made on the design of intranasal drug delivery systems of central nervous system therapeutics to the brain, focusing in particular on stimuli-responsive hydrogels.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available