Journal
CANCER DISCOVERY
Volume 11, Issue 4, Pages 960-970Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/2159-8290.CD-20-1376
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Funding
- Broad Institute-Israel Science Foundation Collaborative Project Award
- Mark Foundation Emerging Leader Award
- Sontag Foundation Distinguished Scientist Award
- NIH [R37CA245523, K12CA090354]
- Zuckerman STEM Leadership Program
- Mexican Friends New Generation
- Benoziyo Endowment Fund
- Human Frontiers Science Program
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This article discusses the recent advances in single-cell expression profiling in tumor research and emphasizes the powerful insights gained from these studies in key aspects of tumor biology, particularly in the context of intratumor heterogeneity.
Human tumors are composed of diverse malignant and nonmalignant cells, generating a complex ecosystem that governs tumor biology and response to treatments. Recent technological advances have enabled the characterization of tumors at single-cell resolution, providing a compelling strategy to dissect their intricate biology. Here we describe recent developments in single-cell expression profiling and the studies applying them in clinical settings. We highlight some of the powerful insights gleaned from these studies for tumor classification, stem cell programs, tumor microenvironment, metastasis, and response to targeted and immune therapies. Significance: Intratumor heterogeneity (ITH) has been a major barrier to our understanding of cancer. Single-cell genomics is leading a revolution in our ability to systematically dissect ITH. In this review, we focus on single-cell expression profiling and lessons learned in key aspects of human tumor biology.
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