Journal
ACS CATALYSIS
Volume 11, Issue 8, Pages 4644-4649Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.1c01102
Keywords
cross-electrophile coupling; C-F activation; C-O activation; nickel; arylation
Categories
Funding
- MEXT [17H06091]
- Grants-in-Aid for Scientific Research [17H06091] Funding Source: KAKEN
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In this study, a Ni-catalyzed cross-electrophile coupling between C(sp(2))-F bonds in ortho-fluoro-substituted aromatic amides and C(sp(2))-Cl bonds in aryl chlorides was reported. The reaction, using Zn as a reductant and (LiOBu)-Bu-t as a base, with LiCl and ZnCl2 as additives, displayed excellent functional group tolerance and a broad substrate scope. Furthermore, the reaction was also applicable to cross-electrophile coupling between C(sp(2))-F and C(sp(2))-O bonds in an aryl tosylate and a triflate derivative.
Ni-catalyzed cross-electrophile coupling between C(sp(2))-F bonds in ortho-fluoro-substituted aromatic amides and C(sp(2))-Cl bonds in aryl chlorides in the presence of Zn as a reductant and (LiOBu)-Bu-t as a base, and LiCl and ZnCl2 as additives is reported. The reaction displayed excellent functional group tolerance and a broad substrate scope. The reaction was also applicable to cross-electrophile coupling between C(sp(2))-F and C(sp(2))-O bonds in an aryl tosylate and a triflate derivative.
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