4.8 Article

Mn-Catalyzed Electrooxidative Undirected C-H/P-H Cross-Coupling between Aromatics and Diphenyl Phosphine Oxides

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Summary: This one-pot cascade transformation involves electrochemically driven azidation of 2H-indazole followed by coarctate fragmentation to synthesize the 2-azo-benzonitrile motif. The manganese-catalyzed transformation is external-chemical-oxidant-free and operates at ambient temperature under air, with up to 89% isolated yield. Diverse derivatization of the 2-azo-benzonitrile product has led to the formation of other valuable scaffolds.

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