Journal
NATURE COMMUNICATIONS
Volume 12, Issue 1, Pages -Publisher
NATURE RESEARCH
DOI: 10.1038/s41467-021-22279-w
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Funding
- ERC Advanced Grant Artisym [694120]
- Dutch Ministry of Education, Culture and Science [024.001.035]
- NWO-NSFC [792.001.015]
- European Union's Horizon 2020 research and innovation program Marie Sklodowska-Curie Innovative Training Networks Nanomed [676137]
- Ser Cymru II program
- European Union's Horizon 2020 research and innovation program under the Marie Skodowska-Curie grant [663830]
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Aggregation-induced emission (AIE) technology has been a valuable tool in nanoscience, particularly in biomedical fields. Researchers have developed phototactic/phototherapeutic nanomotors using AIEgenic nanomaterials, demonstrating their potential for applications in photodynamic therapy.
Aggregation-induced emission (AIE) has, since its discovery, become a valuable tool in the field of nanoscience. AIEgenic molecules, which display highly stable fluorescence in an assembled state, have applications in various biomedical fields-including photodynamic therapy. Engineering structure-inherent, AIEgenic nanomaterials with motile properties is, however, still an unexplored frontier in the evolution of this potent technology. Here, we present phototactic/phototherapeutic nanomotors where biodegradable block copolymers decorated with AIE motifs can transduce radiant energy into motion and enhance thermophoretic motility driven by an asymmetric Au nanoshell. The hybrid nanomotors can harness two photon near-infrared radiation, triggering autonomous propulsion and simultaneous phototherapeutic generation of reactive oxygen species. The potential of these nanomotors to be applied in photodynamic therapy is demonstrated in vitro, where near-infrared light directed motion and reactive oxygen species induction synergistically enhance efficacy with a high level of spatial control. Induced motion has emerged as a method to increase the efficacy of delivery and therapeutic outcomes using nanomaterials. Here, the authors report on a Janus gold shell polymersome with aggregation-induced emission molecules for phototactic and photodynamic therapy applications.
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