1/f-noise-free optical sensing with an integrated heterodyne interferometer

Optical evanescent sensors can non-invasively detect unlabeled nanoscale objects in real time with unprecedented sensitivity, enabling a variety of advances in fundamental physics and biological applications. However, the intrinsic low-frequency noise therein with an approximately 1/f-shaped spectral density imposes an ultimate detection limit for monitoring many paramount processes, such as antigen-antibody reactions, cell motions and DNA hybridizations. Here, we propose and demonstrate a 1/f-noise-free optical sensor through an up-converted detection system. Experimentally, in a CMOS-compatible heterodyne interferometer, the sampling noise amplitude is suppressed by two orders of magnitude. It pushes the label-free single-nanoparticle detection limit down to the attogram level without exploiting cavity resonances, plasmonic effects, or surface charges on the analytes. Single polystyrene nanobeads and HIV-1 virus-like particles are detected as a proof-of-concept demonstration for airborne biosensing. Based on integrated waveguide arrays, our devices hold great potentials for multiplexed and rapid sensing of diverse viruses or molecules. Suppressing 1/f-shaped low-frequency noise is critical but fundamentally challenging to both electrical and optical transducers. Here, the authors demonstrate a 1/f-noise-free optical sensor with integrated CMOS-compatible heterodyne interferometer and an upconversion amplifying technique, which suppresses the noise by two orders of magnitude.

Automated summary

Optical evanescent sensors have proposed a 1/f-noise-free optical sensor through an up-converted detection system, achieving a significant suppression of sampling noise amplitude in a CMOS-compatible heterodyne interferometer. This advancement allows for label-free single-nanoparticle detection down to the attogram level, showing great potential for airborne biosensing and rapid sensing of diverse viruses or molecules.