Some Indian herbs have protective effects against deleterious effects of ochratoxin A in broiler chicks

A protective effect of two herbs, Glycyrrhiza glabra and Tinospora cordifolia, given as feed additives was observed against the growth inhibitory effect of ochratoxin A (OTA) and associated immunosuppression and biochemical or pathomorphological changes. The feed levels of 3 mg/kg OTA and fine powder of one of both herbs were given during a period of 32 days to female broiler chicks divided into 3 experimental and 1 control groups (14 chicks per group). The observed pathological and biochemical changes, the changes in relative organs' weight and body weight, and the decrease of antibody titer against Newcastle disease were more pronounced in the OTA-treated chicks without herbal supplementation, and less pronounced in the chicks treated additionally with G. glabra or T. cordifolia as was shown by the better feed performance and the higher body weight in the chicks treated with the herbs. The higher relative weight of lymphoid organs of the chicks supplemented with both herbs revealed their beneficial effects on the immune system. The hepatoprotective effect of both herbs was evident, being stronger in the chicks additionally supplemented with G. glabra shown by the pathomorphological findings and by the lower levels of aspartate transaminase (131.1 U/l) compared to chicks given only OTA (156.0 U/l). A protective effect of T. cordifolia on the bone marrow and kidneys was found as was shown by the lower levels of uric acid (382.9 mu mol/l) compared to chicks given only OTA (466.9 mu mol/l).

Automated summary

The study showed that the herbs Glycyrrhiza glabra and Tinospora cordifolia, as feed additives, had a protective effect against the growth inhibitory effect of ochratoxin A (OTA) in female broiler chicks. They demonstrated beneficial effects on the immune system, liver, bone marrow, and kidneys, resulting in better feed performance, higher body weight, and lower levels of aspartate transaminase and uric acid in the supplemented chicks compared to those given only OTA.