Journal
EPIGENOMICS
Volume 13, Issue 7, Pages 549-560Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/epi-2020-0380
Keywords
bromodomain proteins; DNA methylation; histone acetylation; histone methylation; histone modifications; rheumatoid arthritis
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The review highlights the key epigenetic modifications in different cell types associated with rheumatoid arthritis and discusses potential therapeutic targets focusing on epigenetic markers. It emphasizes the importance of altered epigenetic regulation in promoting the destructive behavior underlying disease pathogenesis.
Rheumatoid arthritis is a complex, inflammatory autoimmune disease, which is characterized by pain, swelling and joint damage driven by the altered behavior of a number of different cell types such as synovial fibroblasts macrophages and lymphocytes. The mechanism underlying pathogenesis is unclear but increasing evidence points to altered epigenetic regulation within these cell types which promotes the activated destructive behavior that underlies disease pathogenesis. This review summarizes the key epigenetic modifications in the most important cells types in rheumatoid arthritis, which are associated with disease activity. We also discuss emerging avenues of research focusing on readers of epigenetic markers which may serve to be potential therapeutic targets.
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