Journal
EPIGENOMICS
Volume 13, Issue 9, Pages 699-713Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/epi-2020-0449
Keywords
ceRNA network; Creb5; Gas5; lncRNA; renal fibrosis
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Funding
- National Natural Science Foundation of China [31571178, 31771578]
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The study constructed a ceRNA network associated with renal fibrosis, revealing that Gas5 may regulate extracellular Fn1 deposition by targeting the transcription factor Creb5. This provides a theoretical basis for the ceRNA regulation mechanism of Gas5 and offers experimental evidence supporting Gas5 targeting in the treatment of renal fibrosis.
Aim: Although studies on lncRNAs in renal fibrosis have focused on target genes and functions of lncRNAs, a comprehensive interaction analysis of lncRNAs is lacking. Materials & methods: Differentially expressed genes in renal fibrosis were screened, and the interaction between lncRNAs and miRNAs was searched. Results: We constructed a ceRNA network associated with renal fibrosis, by which we found the transcription factor Creb5, a target gene of lncRNA Gas5 that might regulate extracellular Fn1 deposition. Conclusion: Our study not only provides a theoretical basis for the ceRNA regulation mechanism of Gas5 but also provides experimental evidence supporting the use of Gas5 targeting in the treatment of renal fibrosis.
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