Journal
ACS MEDICINAL CHEMISTRY LETTERS
Volume 12, Issue 5, Pages 672-676Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsmedchemlett.1c00200
Keywords
Acanthamoeba; Balamuthia; Naegleria; Trophozoite; Cyst
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Targeting both the hardy structure of the cyst state and the active trophozoite form of the parasite can provide target-directed inhibition as an effective drug strategy in eradicating parasites.
Here we discuss the potential value of targeting both the hardy structure of the cyst state of the parasite, in addition to the active trophozoite form, to provide target-directed inhibition as a viable drug strategy in the effective eradication of parasites.
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