Journal
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
Volume 13, Issue 10, Pages -Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a037929
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Funding
- National Institutes of Health (NIH) [AI105343, AI0826 30, AI112521, AI115712, AI117718, AI108545, AI117950]
- Stand Up 2 Cancer (SU2C)
- KANAE Foundation for the Promotion of Medical Science Grant Award
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The article discusses the heterogeneity and diversity among CD8 T-cell subsets, focusing on differentiation and maintenance of memory and exhausted CD8 T cells, as well as the impact of intrinsic and extrinsic factors. It also explores the nomenclature of effector, memory, and exhausted CD8 T cells, and how new findings about these cell types may affect the development of immunotherapies targeting them in chronic infections and cancer.
Immunological memory and exhaustion are fundamental features of adaptive immunity. Recent advances reveal increasing heterogeneity and diversity among CD8 T-cell subsets, resulting in new subsets to annotate and understand. Here, we review our current knowledge of differentiation and maintenance of memory and exhausted CD8 T cells, including phenotypic classification, developmental paths, transcriptional and epigenetic features, and cell intrinsic and extrinsic factors. Additionally, we use this outline to discuss the nomenclature of effector, memory, and exhausted CD8 T cells. Finally, we discuss how new findings about these cell types may impact the therapeutic efficacy and development of immunotherapies targeting effector, memory, and/or exhausted CD8 T cells in chronic infections and cancer.
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