Journal
FRONTIERS IN CELLULAR NEUROSCIENCE
Volume 15, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fncel.2021.653367
Keywords
intracerebral hemorrhage; mesenchymal stem cells; different species; pathological microenvironment; optimizing strategy
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Funding
- National Natural Science Foundation of China [11972099, 31600770]
- Chongqing Research Program of Basic Research and Frontier Technology [cstc2018jcyjAX0836, cstc2019jcyjmsxmX0753]
- Southwest University of Science and Technology [18zx7128]
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Intracerebral hemorrhage (ICH) is a leading cause of death and long-term disability worldwide. Research has shown that mesenchymal stem cell (MSC) therapy can improve neuronal defects caused by ICH, but key issues regarding the survival, differentiation, and safety of grafted MSCs still need to be resolved for clinical translation.
Intracerebral hemorrhage (ICH) is one of the leading causes of death and long-term disability worldwide. Mesenchymal stem cell (MSC) therapies have demonstrated improved outcomes for treating ICH-induced neuronal defects, and the neural network reconstruction and neurological function recovery were enhanced in rodent ICH models through the mechanisms of neurogenesis, angiogenesis, anti-inflammation, and anti-apoptosis. However, many key issues associated with the survival, differentiation, and safety of grafted MSCs after ICH remain to be resolved, which hinder the clinical translation of MSC therapy. Herein, we reviewed an overview of the research status of MSC transplantation after ICH in different species including rodents, swine, monkey, and human, and the challenges for MSC-mediated ICH recovery from pathological microenvironment have been summarized. Furthermore, some efficient strategies for the outcome improvement of MSC transplantation were proposed.
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