Journal
VIRUSES-BASEL
Volume 13, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/v13050774
Keywords
fludarabine; Zika virus; Severe fever with thrombocytopenia syndrome virus; Enterovirus A71; antiviral drugs
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Funding
- Natural Science Foundation of Jiangsu Province of China [BK20190307]
- National Natural Science Foundation of China [81971923]
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This study demonstrates that fludarabine effectively inhibits RNA virus infections with low cytotoxicity, suggesting its potential development as a broad-spectrum anti-RNA virus therapeutic agent.
Viral infections are one of the leading causes in human mortality and disease. Broad-spectrum antiviral drugs are a powerful weapon against new and re-emerging viruses. However, viral resistance to existing broad-spectrum antivirals remains a challenge, which demands development of new broad-spectrum therapeutics. In this report, we showed that fludarabine, a fluorinated purine analogue, effectively inhibited infection of RNA viruses, including Zika virus, Severe fever with thrombocytopenia syndrome virus, and Enterovirus A71, with all IC50 values below 1 mu M in Vero, BHK21, U251 MG, and HMC3 cells. We observed that fludarabine has shown cytotoxicity to these cells only at high doses indicating it could be safe for future clinical use if approved. In conclusion, this study suggests that fludarabine could be developed as a potential broad-spectrum anti-RNA virus therapeutic agent.
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