Journal
VIRUSES-BASEL
Volume 13, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/v13050895
Keywords
saliva; viral load; COVID-19; nasopharyngeal; SARS-CoV-2
Categories
Funding
- Curaden AG, Kriens, Switzerland
- Laboratory Systemic Health Care, University of Lyon, France [EA4129]
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The study showed that self-collected pure saliva samples are comparable to nasopharyngeal swabs in detecting SARS-CoV-2 viral load in asymptomatic, mild COVID-19 patients, with a significant correlation in viral load between the two sample collection methods.
The aim of this study was to determine whether self-collected pure saliva (SCPS) is comparable to nasopharyngeal (NP) swabs in the quantitative detection of SARS-CoV-2 by RT-PCR in asymptomatic, mild patients with confirmed COVID-19. Thirty-one patients aged from 18 to 85 years were included between 9 June and 11 December 2020. A SCPS sample and a NP sample were taken for each patient. Quantitative PCR was performed to detect SARS-CoV-2 viral load. Results of SCPS vs. NP samples testing were compared. Statistical analyses were performed. Viral load was significantly correlated (r = 0.72). The concordance probability was estimated at 73.3%. In symptomatic adults, SCPS performance was similar to that of NP swabs (Percent Agreement = 74.1%; p = 0.11). Thus, the salivary test based on pure oral saliva samples easily obtained by noninvasive techniques has a fair agreement with the nasopharyngeal one in asymptomatic, mild patients with a confirmed diagnosis of COVID-19.
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