The Antiviral Activities of Poly-ADP-Ribose Polymerases

The poly-adenosine diphosphate (ADP)-ribose polymerases (PARPs) are responsible for ADP-ribosylation, a reversible post-translational modification involved in many cellular processes including DNA damage repair, chromatin remodeling, regulation of translation and cell death. In addition to these physiological functions, recent studies have highlighted the role of PARPs in host defenses against viruses, either by direct antiviral activity, targeting certain steps of virus replication cycle, or indirect antiviral activity, via modulation of the innate immune response. This review focuses on the antiviral activity of PARPs, as well as strategies developed by viruses to escape their action.

Automated summary

PARPs are enzymes responsible for a reversible post-translational modification involved in various cellular processes, including DNA damage repair, chromatin remodeling, translation regulation, and cell death. Recent studies have highlighted the role of PARPs in host defense against viruses, as well as strategies developed by viruses to evade their actions.