Journal
VIRUSES-BASEL
Volume 13, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/v13040665
Keywords
hemorrhagic fever with renal syndrome; bunyavirus; IgM; CTLs; reservoir
Categories
Funding
- Program of Founding Research Centers for Emerging and Reemerging Infectious Diseases, MEXT, Japan
- Global COE program (Establishment of International Collaboration Centers for Zoonosis Control)
- Ministry of Health, Labor and Welfare [H22-emerging-ippan-006]
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Experimentally infected rats showed transient IgM production followed by increased IgG response and avidity maturation, while naturally infected rats had simultaneous high rates of IgM and IgG antibodies, with most of them developing chronic infection. IgG avidity in female rats was associated with decreased viral load in the lungs, in contrast to male rats where no relationship was observed.
To clarify the mechanism of Seoul orthohantavirus (SEOV) persistence, we compared the humoral and cell-mediated immune responses to SEOV in experimentally and naturally infected brown rats. Rats that were experimentally infected by the intraperitoneal route showed transient immunoglobulin M (IgM) production, followed by an increased anti-SEOV immunoglobulin G (IgG) antibody response and maturation of IgG avidity. The level of SEOV-specific cytotoxic T lymphocytes (CTLs) peaked at 6 days after inoculation and the viral genome disappeared from serum. In contrast, naturally infected brown rats simultaneously had a high rate of SEOV-specific IgM and IgG antibodies (28/43). Most of the IgM-positive rats (24/27) had the SEOV genome in their lungs, suggesting that chronic SEOV infection was established in those rats. In female rats with IgG avidity maturation, the viral load in the lungs was decreased. On the other hand, there was no relationship between IgG avidity and viral load in the lungs in male rats. A CTL response was not detected in naturally infected rats. The difference between immune responses in the experimentally and naturally infected rats is associated with the establishment of chronic infection in natural hosts.
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